My partner has been on enzalutamide for about 8 months. He had a spinal cord compression in October 2020 and has been unable to walk since - he was progressing in hospital, can move his legs but has little muscle strength. They discharged him in November because of a covid outbreak, since when his physiotherapy has gone from daily to once a week (if he's lucky). |He has some exercises to do, and is recommended to at least stand every day with the transfer aid, but a lot of the time he is too tired to even attempt it. His calcium has been reduced to a normal level after treatment. The oncology registrar today suggested they may recommend a break from (or dose reduction of) the enzalutamide, on the grounds of improving his QOL, that chemo would be an option if he were stronger. Does anyone have any experience of taking breaks from enzalutamide? We don't know if his inability to increase his mobility relates to the spinal cord damage itself, or the lack of physiotherapy, or the fatigue from the enzalutamide.