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Zoladex side-effects

User
Posted 16 Jan 2017 at 10:07

The day after my second Zoladex hormone implant on 22 May 2015 I developed a sharp pain in my left wrist and more general pain in the left arm. By the afternoon of the following day (24 May) I could not bear it any longer and went to the local NHS walk-in centre and I was diagnosed with carpel tunnel syndrome. I searched on the Internet and found that this side effect had been reported a few times in the USA, but not apparently in the UK. My doctor, however, changed the diagnosis to a trapped nerve in my shoulder. I was not convinced by this! I went online and asked the NHS if anyone had reported similar side-effects. After several reminders, more than 12 months later I was told that no such side effects had been reported. I am not convinced that they even bothered to check. Following my latest Zoladex hormone implant on 30 December 2016, the day after I developed stiffness and pain in my left knee. As I suffer from arthritis I thought perhaps that this had flared up in my left knee, but as the days passed I realised that this was running the usual course of an arthritis inflammation and wondered if this too was a side-effect of the Zoladex hormone implant.When I checked online I found that at least one other person in the UK had the same experience, in 2015. Does anyone know whether these are the only two incidents of this side effect in the UK?

I am puzzled as to why I should such side effects on only two occasions out of eight, and wonder whether the NHS supplies of Zoladex are sourced from this country alone or whether they are sourced from different countries. I intend to ask my doctor to follow this up but would be glad to hear from anyone with any information on this.

User
Posted 16 Jan 2017 at 18:58

Can't help with your query Hel but bumping in case somebody else can

We can't control the winds - but we can adjust our sails
User
Posted 16 Jan 2017 at 19:38

Hi HEL,

I think the thing to bear in mind with Zoladex, is not the actual drug itself, it's side effects are minimal, compared with the intended effects that hormone therapy has on your body.

What all of these hormone therapies have in common is that they stop your body making testosterone, and testosterone is that all important hormone that made a man of you!

Your body started making testosterone when puberty kicked in, it was testosterone that made your beard grow, your muscles grow and your wedding tackle grow, without testosterone you will revert to having the body of a 60 year old boy.  

When I was on Zoladex and later on Prostrap, my beard still grew enough to just about justify shaving in the morning, however I didn't really need another shave in the evening to get rid of the 5 o'clock shadow.  More noticeable was the way the hairs diminished on the rest of my body.  But those are just the externally noticeable effects.  Hormone therapy causes the bones to thin, as old men without testosterone we are just like old women and prone to osteoporosis, and our muscles will grow smaller and loose their strength, so none of this will help arthritic joints.

What can we do about it?

Personally I persuaded my GP to put me on a junior aspirin every day, there is some evidence it fights cancer, it thins the blood leading to better circulation and it is a bit anti-inflammatory.

Another trick, is to pig out on a high dose of Ibuprofen.  Apparently you need to take Ibuprofen for about 3 days before it has an anti-inflammatory effect, and you mustn't take it too long either, its a sort of Goldilocks thing, not too little and not too much.  You need to get the strongest tablets from behind the chemists counter and take them for a week, take whatever the back of the packet recommends as the maximum daily dose, every day for a week, then stop to let your body recover, repeat every 2 to 3 months.

Finally, there is apparently some chemical found in apple skin that combats muscle loss in the elderly, so an apple a day, but don't peal it.

:)

Dave   

Edited by member 16 Jan 2017 at 19:45  | Reason: Not specified

User
Posted 17 Jan 2017 at 10:08

I'm puzzled why you are so convinced that the Zoladex is to blame; it ain't necessarily so.

User
Posted 20 Jan 2017 at 11:33

I appreciate your well-meaning responses. I am not totally convinced that Zoladex is responsible. Just highly suspicious. That is why I am trying to find out whether other people have similar experiences and their prevalence. I am aware of the efficacy of the treatment and its side effects. In fact I experience these on a daily basis, as I suspect many others do. These two reactions though were painful and debilitating and if Zoladex is responsible it needs to be brought to people's attention. Many thanks again for taking the time to respond to my post.

User
Posted 25 Jan 2017 at 13:59

I seem to have developed arthritis in my right thumb and first finger since my second implant.

May be coincidence, may not. Never had it before though.

User
Posted 25 Jan 2017 at 16:53

My doctor usefully supplied the date of administration. name of the supplier, batch number and website address https://yellowcard.mhra.gov.uk (tel: 0808 100 3352) for reporting suspected side effects. Not able to supply location of manufacturer though. I intend to write to AstraZeneca UK, who produce Goserelin Acetate under the brand name Zoladex LA, and to report my suspicions at the above web address.

User
Posted 25 Jan 2017 at 18:27

The only time I needed physio was whilst on Zoladex. Upper Arm tendon shortening was deemed to be the problem. My understanding is Astra give tendon shortening and displacement as a side effect. Tendon issues also arise in arthritis?

Ray

User
Posted 26 Jan 2017 at 11:11

http://www.ehealthme.com/ds/zoladex/arthritis/

User
Posted 26 Jan 2017 at 21:08

hi,i am suffering from osteoarthritis of my hips after been on zoladex for 2yrs 4 mths.

User
Posted 27 Jan 2017 at 01:55

My OH Suffers from painful Achilles also has arthritis in knees which has got worse mainly due to muscle wastage
Debby

 
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