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Docetaxel Chemo – the highs and the lows

User
Posted 13 Dec 2016 at 16:28

For what it's worth, I had a look at the copious notes we kept on Tony's treatment (also at Torbay, Gromit!) while on Docetaxel. He was always reporting me about his bowel movements (or lack of same), and I'm afraid I just used to put my fingers in my ears and go, "La-la-la, just sort it!".
It seems the only antiemetic he was given, or needed, was the one they give intravenously at the time of the infusion. He settled on taking 2 doses of Laxido on Days 1, 2 and 3, then one dose on Day 4, after which normal functioning was restored.
He didn't bother with the pineapple and didn't have any but the briefest distortion of taste. He continued to enjoy wine and beer after the first week of the cycle.
Laxido became a daily necessity later on, once morphine pain relief was used, but the doses stated above seemed to sort him out during the chemo. He tolerated the chemo extremely well, and the only complications were a couple of infections, one of which entailed being taken into the hospital for three days in an isolation ward.
Sadly, the early chemo didn't apparently do much to prolong his life, but I suppose for everyone who gets minimal benefit, there is someone else who derives huge gains from it. Let's hope you guys are among those for whom it kicks this horrid disease into the long grass for a good while.

Marje

User
Posted 13 Dec 2016 at 17:42


It's worth a lot, a hell of a lot, thanks Marje.


Noted for Infusion 4 if my veggie fix doesn't work.

User
Posted 13 Dec 2016 at 18:06

Marje, I think we are of similar mind here. David hates getting bunged up and I'm sympathetic but there's not much more I can do except shove loads of vegetables into him! I hope one of these strategies using Laxido etc. resolves the problem. If not, I'll continue with the sympathy and be very happy to see a smiley face emerging from the bathroom. But I don't need a running commentary so I'll be keeping fingers for the ears at the ready!

Linda

User
Posted 16 Dec 2016 at 12:14

Infusion 2 Day 11


Half way through purdah again and it's same old, same old. I feel just the same as I did at this time in the last infusion cycle.


For the record, here is the list of the potential side effects of Docetaxel Chemo as defined by Macmillan cancer support and my current status in respect of these.


Risk of infection – No.


Bruising and bleeding – No.


Anaemia – No.


Feeling sick – No.


Diarrhoea – No.


Loss of appetite – No.


Sore mouth – No.


Taste change – No.


Peripheral neuropathy – No.


Hair loss – Yes. Booo Hooo! Me hairs coming out! I'm moulting. It won't be long before I'm polishing the top of me 'ead. http://community.prostatecanceruk.org/editors/tiny_mce/plugins/emoticons/img/smiley-tongue-out.gif


Skin changes – No.


Nail changes – No.


Build up of fluid – No.


Muscle/joint pain – No.


Shortness of breath – No.


Eye problems – No.


Hand-foot syndrome – No.


Blood clot – No.

User
Posted 16 Dec 2016 at 18:54

I hope you are going to change your profile picture at the appropriate time?

You are doing great - have a wonderful Christmas with food that tastes proper x

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard
User
Posted 16 Dec 2016 at 20:40

Originally Posted by: Online Community Member


I hope you are going to change your profile picture at the appropriate time?



He he! That will be a bit of a wardrobe challenge. Apart from my ColU shirt, I haven't got a thing to wear. http://community.prostatecanceruk.org/editors/tiny_mce/plugins/emoticons/img/smiley-wink.gif


Originally Posted by: Online Community Member


You are doing great - have a wonderful Christmas with food that tastes proper x



Thank you. I hope you and John also have a great Christmas.

User
Posted 22 Dec 2016 at 21:44

Infusion 2 Day 17


Last update before Infusion 3 next Wednesday. Nothing has changed, happy days! For any of you contemplating chemo, I can't guarantee your bodies will react in the same way as mine. I'm only 20% of the way through. Things may change and get tougher but they may not. I have no regrets taking this course of action and I honestly believe that you can approach it too without fear. The NHS seems to be getting pretty good at this chemo stuff.


Mrs_C is going to fatten me up, Pheasant and Pyne's Farm free range chicken for Christmas Day (separate birds, not an all in 1) followed by Diplomat pudding. Yum yum yum.


G&T, check. Dark rum and coke for Mrs_C, check. Various red and white wines, check. Bottle of my home made Orange wine, check. Bottle of Sauternes to go with sweet course, check. Bottle of 10 year old tawny port. check. And, most importantly, plenty of lovely real ales, check.


I will be fattened and pickled.


Happy Christmas all and I wish us all the most joyous new year for ourselves and our loved ones (and Colchester United).


David


 

User
Posted 28 Dec 2016 at 22:44

Infusion 3 Day 1


Infusion 3 completed without any problems.


My resolve to consume loads of vegetables and no meat in the day or two before the infusion and for the two days after in order to combat The Basturds, weakened in the face of Christmas leftovers, so I've adopted Gromit's and Marje's advice to use Laxido.


So to the scores on the doors. My PSA has dropped from 13.28 to 7.44 and all other bloods results were good. I know these drops won't go on for ever but I have to say:


'Woop de dozzy do! Go on my son, get in there!'


If you could synthesize, bottle and sell, the feeling of elation I got when hearing these results, then you would be a multi-zillionaire. It was as good as watching your team smack in a last gasp cracker to win the local derby game, 5-4.


I'm going to ride this wave for as long as it will support me. This old dog is going to wag his tale for a while yet.


I might have a cheeky beer tomorrow night.

Edited by member 29 Dec 2016 at 11:13  | Reason: Not specified

User
Posted 29 Dec 2016 at 09:27

So glad to hear your news, and that the treatment isn't impairing your good spirits. This time last year, Tony's blood tests were the best since diagnosis, thanks to the wondrous effects of Enzalutamide - the best Christmas present he could have had! Yes, ride that wave and make the most of every day (and every pint, and every turkey sandwich - just balance it all out with some more sprouts!).
Good luck with the rest of the chemo, David.

Marje

User
Posted 29 Dec 2016 at 22:32
Hi david
Great to see your psa reading has dropped! Keep riding that wave with joy.
Lovely reading your doxetaxil comentary.
Lesley x
User
Posted 30 Dec 2016 at 21:10
Keep Wagging that tale David (also my brothers name).
Fab Fab news on the PSA .
I am loving your updates bringing fun, bringing humour , bringing reality, bringing help and advise to new newbies, but best of all bringing your unique and lovely personality to the forum.
Keep going you are doing such a wonderful job.
A very happy new year. Xx
BFN
Julie X
NEVER LAUGH AT A LIVE DRAGON
User
Posted 01 Jan 2017 at 12:55

Infusion 3 Day 5


My thanks to Gromit and Marje whose advice has been spot on.


More graphic details follow so if you are not taking or don't have any problems in taking Ondansetron then you don't need to read further.


As I understand it, Ondansetron is a drug that has an adverse effect on peristalsis and thus can cause constipation.


Prior to my infusion last Wednesday, I talked to the chemo nurse about whether I still needed Ondansetron. Her answer was along the lines of 'it's your body and therefore your choice'. I decided that whilst I hate being constipated, that I hate throwing up even more. Therefore, I decided to continue with the Ondansetron.


Last Tuesday, I took one Laxido after breakfast and one after dinner. On Wednesday, the day of the infusion, I did the same and took one Dulcolax before going to bed. On Thursday I had two small movements which were nowhere near a normal day's output but, most importantly, the movements were soft and needed no straining. I took one Laxido after breakfast and one after dinner on Thursday and one Dulcolax before going to bed.


On Friday, movements returned to normal with a consequent increase in volume to compensate for limited output the previous day. Movements were soft and needed no straining. I took one Laxido after breakfast on Friday and then nothing further. Since then, my bowels have been perfect.


FYI Ondansetron was administered by infusion on Wednesday afternoon and then by pill Wednesday evening, Thursday morning and Thursday evening. I decided not to take the Ondansetron pills on Friday morning or evening and suffered no adverse consequences.


I recommend trying the above course of action if Ondansetron is causing you problems.

User
Posted 03 Jan 2017 at 14:29

Glad everything is going well David.

Again my husband is one day behind you on cycle 3.

Unfortunately he's having a tough time because we all caught the horrible cold/cough virus that is going round. Although he temp was ok I was getting very concerned about him because he was really quite unwell so he has seen GP today. GP was very good and has given him some antibitotics as a precaution and is also giving him a full blood test in two days to double check his white blood cell count.

(I feel sorry for the poor Queen if this is the virus she has. I've never been wiped out by q cold in the same way before and I'm nowhere near 90 :-) !

User
Posted 03 Jan 2017 at 14:41

Sally,


I really think you should be ringing the Chemo ward to tell them about this. It has been made clear to me in no uncertain terms that if I get an infection, don't go to your GP, do ring us. The problem with an infection is if things go bad then sepsis is a real danger. Please ring them.


David

User
Posted 03 Jan 2017 at 15:01
Hi David
Thank you for the message. Yes he is in touch with the chemo unit too. Between the two of them they are looking after him very well but it is very nerve wracking with the sepsis risk.
User
Posted 03 Jan 2017 at 15:42

You could certainly have done without that...did you manage to have any sort of a Christmas break before the virus hit? Hope you got up to see the family and that there were people on hand to nurse you as well as your husband - sounds as if you are both knocked for six.


Do hope that you are both on an even keel again before too long and that the chemo is doing its job. Any sign of a Warwick offer to cheer everyone up?


Take care.


Eleanor

User
Posted 03 Jan 2017 at 17:20

Originally Posted by: Online Community Member
Any sign of a Warwick offer to cheer everyone up?


I'm probably suffering from terminal thickness, but, what's a Warwick offer?

User
Posted 03 Jan 2017 at 22:58
Hi Eleanor we had Christmas Eve and Christmas Day with family before this hit which I'm so grateful for.
I'm really hoping that the antibiotics do some good because this has really knocked him for six. We had been so careful in trying to avoid viruses but so many people seem to have it.

David - one of my sons is waiting to see if he gets an offer from Warwick University :-) Eleanor - still waiting. He may not hear anything until the end of the month.
User
Posted 10 Jan 2017 at 16:37

Infusion 3 Day 14


Update time. I'm now recognising some patterns. Days 4 to 6 of this cycle I felt pretty crappy. The same thing happened in the first two cycles but not for so long. Anyway, I'm prepared for it now, it's a cost of the chemo treatment. 2 or 3 crappy days out of 21, I can live with that.


I've got a few more side effects.


Bruising - This lasts for a long time at the site of the canula that administers the infusion. It looks horrible but doesn't hurt one iota.


Peripheral neuropathy - I've developed this in some fingers and toes. It's not too bad but I will tell my Onco about it at our consultation next Tuesday.


Hair loss - It's still coming out like a good 'un. Do I care? Nope!


Nail changes - I'm getting some discoloration in my toe nails. Finger nails still look fine.

User
Posted 17 Jan 2017 at 20:28

Infusion 4 Day 1


Woof, woof, woof .......... wag, wag, wag!


Prior to my consultation with my lovely Onco this morning I was singing silently to myself my favourite Status Quo song, 'Down down, deeper and down':


https://www.youtube.com/watch?v=bNPJuJSVmNA


This song has one of the greatest guitar intros ever.


Anyway, the song worked, my PSA has dropped from 7.44 to 5.04 and all other bloods results were good.


The Onco wasn't concerned about the minor peripheral neuropathy or the minor nail changes.


Infusion 4 completed without any problems.

Edited by member 17 Jan 2017 at 20:38  | Reason: Not specified

 
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