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Any hope for my hubby - metastatic, Gleason 10

User
Posted 17 Nov 2019 at 20:06

Thank you Jasper so very much!

User
Posted 17 Nov 2019 at 20:06

Thank you Franci!!

User
Posted 01 Dec 2019 at 00:29

Arden had first treatment on clinical trial 11/21.  About 5 days prior he had nausea and low grade fever, back pain (symptoms he had when he first got sick and was diagnosed).  On 11/22 he went to work.  11/23 Saturday he was running a fever, nausea and pain in groin.  It went up to 102.5 so I took him to Mayo, Saint Mary's hospital.  He was admitted and released late Sunday night.  Monday his fever broke and off to work he went, worked Tuesday as well.  Felt good overall.  Wednesday started feeling  lousy again.  Thursday in the middle of our Thanksgiving dinner his fever was 104.7.  I took him to the emergency room at the hospital near our house.  He has been there ever since.  His fever went up to 106, severe groin pain, pain in his upper right arm, and back.  Temp today is still 102.8.  Has anyone had immunotherapy type treatment and are these common symptoms?  Anyone have fever along with pain as the PSA goes up and cancer progresses?  His Mayo team is out Thurs - Sunday for the holiday here and the on call team said let the hospital here get him stable and stop taking the oral drug from the trial for now.  We will talk to his Mayo Dr on Monday to see how to proceed.  10 days ago he swam 27 laps at the gym.  Now he cannot even walk or get out of bed at the hospital.  He's lost 12+ lbs in the last week or so.  Thank you!

User
Posted 19 Jan 2020 at 16:40

Jan 19, 2020:

We are two months into the clinical trial.  No improvement in that all tumors & mets still exist and have gotten slightly larger (by millimeters).  One new met in femur.  Most mets are in sternum, spine, and pelvic areas.  two large tumors on each adrenal gland.  

3 hospital stays in Nov and Dec - reaction to treatment (high fever & pain which both go away a week or so after the immunotherapy infusions), and last was admitted on Christmas Eve for 5 days.  Permanent damage to adrenal glands caused a variety of symptoms and he is now on steroids for that.  

Lost a lot of weight, still working half days but will be done soon as disability was approved for now.  He looks gaunt, has no energy or appetite, no motivation to plan or do things, PSA 88 as of 1/2/20.  We don't do a lot.  We both pray a lot and try to stay positive that he has more time.  I can barely keep up with so many people checking in so I created a caringbridge site with updates.  I take care of everything and him and am exhausted.  

Drs don't feel there are a lot of options if this trial does not give him more time.  What about Cabizitaxel?  Or more Doceltaxel?  They said since Enza did not work Abi won't either.  Talked about Radium 223 at one point but they put that on the back burner.  I think about 2nd opinions but Mayo Clinic is considered here in the US (and to other countries as well) the best.  

I could use any encouraging words from you kind folks.  We are only 18 months in, I thought we would have so much time trying different treatments.  

Thank you, 

Saint Paul

User
Posted 19 Jan 2020 at 22:37
Sorry to hear you are running out of options, is Leutinum treatment a available over there?
User
Posted 20 Jan 2020 at 07:34

Yes, as francij1 mentions, Lutetium 177 may be a decent option.

Both I and Valleyboy are undergoing this fairly new treatment presently.

Also, at the clinic I attend, the talk is now of immunotherapy.

Good luck.

Dave

"Incurable cancer does not mean it is untreatable and does not mean it is terminal either"
User
Posted 20 Jan 2020 at 10:30
The trial that Arden is on is a type of immunotherapy. As you say, these drugs are used for other cancers but not prostate so the trial team has a responsibility to call a halt as soon as they are convinced that it isn’t working and / or that the side effects are too severe. You could ask about Lutetium or cabazitaxel.
"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 20 Jan 2020 at 18:12

Thank you all, I had forgotten about the Lutetium 177 I read about in some of your posts.  I jotted it down as well.  Dave I was encouraged to read you are hearing about immunotherapy at your clinic.  Mayo says it traditionally has not been effective for prostate cancer, but.....nonetheless these trials are valuable.  We hope it helps other men down the road.  I understand Docetaxel was once a trail only, I guess most treatments were.  I will put out an update middle of Feb when he has scans again.  

I greatly appreciate the responses.  We knew from the beginning what we were up against.  Fortunately he has no pain.  The only pain now is about a week after infusion in one pelvic area then it goes away after a few days.  

My thanks, 

Judy

User
Posted 12 Feb 2020 at 00:03

My beloved husband Arden is gone now, at home in God's kingdom.  He went quickly and unexpectedly on January 29th early in the morning after a massive brain bleed at home.  He went to work as always on the 28th, was not feeling well later that night and I called paramedics around 9:30pm.  We thought we had many more months at least.  

I am beyond devastated, I don't know how the wives here get through this.  I can't imagine life without him.  I hope he comes for me soon.  Being here alone in our home that we loved is not a life.  

I am encouraged to see so many on here that keep fighting and finding treatments that give them more time.  What a blessing and I pray it continues for all of you.  

Judy in Saint Paul, Minnesota, USA

User
Posted 12 Feb 2020 at 00:53
Judy, I am so, so sorry to read this. I can only wish you a little more of the strength that you have already shown to sustain you in the coming weeks and months.

God be with you x

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 12 Feb 2020 at 01:13

My heart goes out to you Judy.

God Bless xx

User
Posted 12 Feb 2020 at 02:12

Bless you and keep you safe through your grief.

 

User
Posted 12 Feb 2020 at 05:38
So sorry to hear this.
User
Posted 12 Feb 2020 at 07:39

Sorry to hear your sad news.

Thanks Chris

User
Posted 12 Feb 2020 at 08:12

I'm so sorry.  Praying you find the strength to get you through. xx

User
Posted 12 Feb 2020 at 08:52

I am so very sorry to read this Judy. You are in my thoughts.

Shelagh xx

 

 

User
Posted 12 Feb 2020 at 09:38
So sorry to hear this :-(

If life gives you lemons , then make lemonade

User
Posted 12 Feb 2020 at 09:48

Judy

So sorry for your loss.You are in our thoughts and prayers

User
Posted 12 Feb 2020 at 10:10
So sorry to hear of your loss :( xxx

User
Posted 12 Feb 2020 at 12:13
My heart breaks for you,so sorry to hear your very sad news.

May God keep you strong for the difficult times ahead.

Kim xx

 
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