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Abiraterone and SBRT on bone metastases - Experiences? - Abiraterone (Abi),CORE Study,SBRT

User
Posted 02 May 2019 at 11:33

Have you had chemo or enzalutamide? I gather that these are next for me once PSA starts rising. I'm on Prednisolone, Abi and Prostap but I havnt had chemo yet. I've also been told that Radium 223 might be used at some point.

User
Posted 02 May 2019 at 11:39

Are you able to take Enzalutamide once the Abiraterone fails? We were told no

User
Posted 02 May 2019 at 11:51

My Onco told me I could but I have private medical insurance so maybe it’s an NHS thing

User
Posted 02 May 2019 at 13:55
NICE does not approve enza after abi (or vice versa) because all the trial data showed that once one fails, the other will also fail very quickly, adding no benefit to the patient. The exception is where a change from one to the other is proposed within 3 months of starting, usually because of side effects / patient tolerance.

Some can get one after the other as part of a trial or under private health provision but it tends not to be successful for long.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User
Posted 17 Jan 2020 at 12:01
I started this thread in Feb 2018 partly to re-assure myself about starting Abiraterone, which sounded a serious drug, and which I rather feared. So I'm reporting back, as I have just stopped that after two years - my PSA had started rising steadily from about October 2019, reaching 19 before Christmas.

So my Onco has switched me to Chemo with Docetaxel - first session January 2020 ( nine more to go, at 3 week intervals - I'm not looking forward to that either - the initial side effects have been quite unpleasant).

I'm bound to say that Abiraterone was pretty trouble-free - I tolerated it well, with only the usual side effects of hormone treatment, which I had already experienced on Prostap ( which continues). I felt pretty well on it, but with moderate fatigue, plus loss of fitness and reduced muscle mass, weight/fat increased, despite excercise. I like walking, and found I was often struggling on things I could tackle easily before. Could be age too of course - I'm mid- 70's.

So for anyone moving on to Abiraterone treatment, be reassured - it works well, and can be pretty easy to deal with. Having to take tablets an hour before Breakfast, and the monthly blood tests and check-up before they released the next month's tablets sometimes could be a nuisance, but really not much bother. I appreciate that much more, having started chemo ! Just a shame Abiraterone didn't work longer for me.

Good luck anyway, to anyone starting that treatment.

User
Posted 17 Jan 2020 at 16:01

Good luck with the chemo.

Am mid seventies and just finished 6 cycles and side effects not too awful.The advice was to ovoid crowds etc. if possible between 7 to 12 days after you have received chemo. cycle to cut down risk of infections.

Kind Regards

Norm

 
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