Cabazitaxel Next

Cabazitaxel Next

User

Posted 17 Jan 2018 at 06:52

Very best wishes AC.

"Incurable cancer does not mean it is untreatable and does not mean it is terminal either"

User

Posted 17 Jan 2018 at 18:13

Folks, spent an almost enjoyable couple of hours at the Arden Centre this morning. Discovered that nursing staff turnover has been extremely high since I was last there for docetaxel in August. Just about three familiar faces out of a couple of dozen there. Rather worrying! As I was there over lunch time, I experienced the curly cardboard sandwiches again. Note to self - ,bring your own next time! I was given the infusion much as with docetaxel, but Piriton and Ondansetron were delivered via i/v. Usual flush before and after the cabazitaxel infusion. No pills to take beforehand and only prednisolone to be taken daily between cycles. Am off the useless dexamethasone.

Now, it's just a case of waiting to see if there are side effects and then dealing with them. Will report how it goes.

User

Posted 05 Feb 2018 at 18:12

Just had oncologist appointment before starting second cycle. Like Si Ness, I've experienced an initial flare in PSA, which I trust will start to come down in a cycle of two. My PSA went up slightly from 5.9 to 7.3. Unwelcome! My experience was that the cabazitaxel behaved much like the docetaxel did. First day after chemo, when feeling the benefits of the other stuff infused as well as the Cabazitaxel, fine! Days two to five, some nausea for which domperidone wasn't brilliantly successful, but I coped. Thereafter smooth sailing with no side effects. Blood results ok, so onward and upward!

User

Posted 05 Feb 2018 at 18:24

Hi AC

Sorry to hear this but i hope like me you get a drop after the next cycle.

with regard nausea i had Emend three tablets worked wonders one before chemo then one each day after

Don't deny the diagnosis; try to defy the verdict

User

Posted 02 Mar 2018 at 18:22

Is this the one you are looking for AC?

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User

Posted 06 Mar 2018 at 18:34

Lyn. Exactly. Thanks!

Here's the update. Second cycle went reasonably smoothly. Nausea and vomiting first few days. Found domperidone ineffective. Bigger dose needed as I'm a big bloke but not allowed, so I tried metoclopramide which does provide a higher maximum - up to 5 tablets in my case, though I've never gone above four. At the end of the cycle, my PSA had gone down marginally, so hopefully the flare is over.

Writing this just after a couple of days in hospital following vomiting/diahorrea. Food wouldn't digest and came back as though there was no way through. As this persisted over the weekend, I rang the specialist chemo nurse who hauled me in pronto. Side room in case I was infectious, lots of I/v rehydration and anti-nausea medication. Now fine. Lost a stone!

It seems for me the body's behaviour during a cycle just isn't predictable. More in 21 days.

User

Posted 06 Mar 2018 at 18:54

You always sound very positive AC despite your nausea and vomiting.
Hoping the next treatment goes well for you.
Ian.

Ido4

User

Posted 06 Mar 2018 at 19:06

Well every cloud has a silver lining I suppose - some would be thrilled to lose a stone :-/

Stay well, my friend

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard

User

Posted 06 Mar 2018 at 19:16

Ah Lyn, trouble is that half of the weight loss is fluid from my left leg - lymphodoema. Goes straight back on when I get back into my normal pattern. Mind you, I'm being very cautious about booze during the chemo, diet lemonade is my very boring thing! That tends to keep the weight down, too. It seems that being in bed most of the time, so horizontal, the leg loses its liquid. If I could walk around with my left leg wrapped around my right ear, Ministry of Funny Walks style, I'd probably be pretty slim, like John Cleese used to be!

User

Posted 06 Mar 2018 at 22:01

Watching to see how you get on Arthur, can’t think the V&D is much to enjoy but your positive attitude is such a joy to read and I know it can’t be easy to present this way. So far so (nearly) good!

Good luck for number three.

Love Devonmaid

User

Posted 07 Mar 2018 at 18:04

Devonmaid. Thanks for the thoughts but there's no Arthur here! My pseudonym is a protective barrier and doesn't even hint at my true initials. I can confirm that all signs of nausea have been banished but my word it is damned uncomfortable working the constipation from anti-nausea drugs out of my system. A blast it is not!

User

Posted 07 Mar 2018 at 19:08

Hi Ac (arther)
What a bugger ask for amend best anti sickness I have had
Seems like your PSA is following what mine did but you seem to be getting a lot more of the side effects
Should beable to give you some info on the testosterone thing soon
Keep smiling not many cycles left
Si

Don't deny the diagnosis; try to defy the verdict

User

Posted 08 Mar 2018 at 06:53

Hi AC, hope you're feeling better today.
Transport

User

Posted 08 Mar 2018 at 23:50

Hi, AC - still finding my way around this worthwhile site and have just come across your latest posts. Sorry to hear of your ongoing problems which obviously have not been helped by the nasty side effects. Trust all will settle down again soon ...

User

Posted 19 Mar 2018 at 16:34

Update at 19 March. PSA still going down very gently, much more slowly than with docetaxel - 6.9, compared with 7.2 three weeks ago. It had better speed up or ten cycles will only halve it!

Side effects this time were a bit more unpleasant, nausea/vomiting persisted well beyond the first 4/5 days, but this may have been down to my concurrent labyrinthitis, for which the rather unconvincing treatment is exercises involving moving the head horizontally and vertically with eyes open then closed, followed by horizontal movement with focus on a fixed point. MRI scan of my left ear arranged which may throw some light on this irritating condition, whose origin may lie a few years back when I had a prolonged ear ache and gained near deafness in that ear.

Fourth cycle starts in a couple of days. More after that. Onward and upwards - but not in PSA!!

User

Posted 19 Mar 2018 at 16:47

Good luck with the fourth cycle and a better outcome for you.

User

Posted 19 Mar 2018 at 17:13

Hopefully just early days this time.Did medics give any feedback?

Good luck.

Ray

User

Posted 20 Mar 2018 at 17:35

Ray, my oncologist was happy that the inexorable rise whilst I was on steroids only had been stopped and indeed reversed. Not much else to say, really. These are early days: 3/10 cycles completed.

User

Posted 20 Mar 2018 at 18:59

6.9 I dream of that! Currently I’m on 322 and on day 12 of my first of 6 Cabazitaxel infusions. Side effects so far were pain in my right bicep days 2–6 possibly due to anguish from the fact that the first 2 cannulas they put in me weren’t successful so we changed to left arm and all ok. Also from day 8 to 12 (ongoing) I’ve developed a cough and cold which is annoying to say the least. Other than that all ok with 2nd weekly blood tests scheduled for Tmos. Keep the faith folks. J.

User

Posted 21 Mar 2018 at 17:53

Valleyboy, had my fourth infusion today and as usual I reminded the nurse that so far the record is five attempts to get a cannula working. This one got it right the second time. So I know about soreness from the five sites time! I know it's cruel but I can't resist setting them the challenge! Surprising how the skill level varies. I learned that the best do it by feel rather than sight. It also helps if your veins are close to the surface. Mine are pretty well covered and a bit kinky. They like long straight runs, which I don't have. Who'd have thought such a simple thing could be so complex?

Notification

Similar Topics

Join the online community now.