Gleason score is important as it indicates the degree to which the greatest number and next most numerous cancer cells have deviated from normal cells. However, the Gleason arrived at following biopsy is not always what is determined when removed Prostates are examined in the lab. Where these assessments differ, the Gleason is more often upgraded than downgraded. What is of more importance is the staging. If scans/biopsies lead to the consultants believing the cancer is well contained the chances of a Prostatetectomy being successful are improved. If the cancer is about to burst out of the capsule the likelihood of needing to add RT to the surgical operation greatly increases. (RT can go beyond the limits of the knife). In such a situation some men will conclude that they should go straight to RT (usually accompanied with HT) rather than experience the potential side effects of Surgery too.