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Enzo or Abi - any views?

User
Posted 05 Jan 2017 at 19:05

Thanks so much Lesley - both for the hopeful/helpful information and for the loving support and crossed fingers. It's all so much appreciated. Sunshine predicted for us tomorrow but your message cheered me up anyway!


Eleanor


x

User
Posted 06 Jan 2017 at 18:42

Only just seen your post, Eleanor. Yes, it seems to be an either/or thing with these two drugs unless you're on a trial; once you've had one for as long as it works, the other is unlikely to work. Tony was advised that Enza, which I think is slightly newer, was probably better for him because of the side-effect profile and the steroids that go with Abi. But most men will only be able to comment on one or other of these drugs - in some cases there will be a clear reason for one or the other, so the oncologist will probably guide the choice. When you find out the cost of these drugs, you will feel very, very grateful for our NHS!

I hope whichever drug is chosen does the trick and gives you both a good quality of life for many months.

User
Posted 06 Jan 2017 at 19:23

Hi Eleanor
I also am on Stampede J Trial and started on Enza plus abbi (and Prostap) 2 years ago. After about 1/2 months I came off the abbi as it was identified (on a process of elimination) to be the cause of liver and bowel issues. My psa dropped from 235 to under .06 for the last 18 months. I'm fine but with the usual S/effects of hot flushes, weariness etc.
My onc also told me that abbi can also effect the heart so I'm glad I'm not on it as I'm also diagnosed with angina so I'm not doing much running any more..
I hope this helps
Good luck
Paul

Edited by member 08 Jan 2017 at 09:07  | Reason: Not specified

User
Posted 06 Jan 2017 at 20:09

Generally speaking, I think men can do just as well on either but the oncos do sometimes have a very clear instinct that one is going to be better than the other for a specific patient.

"Life can only be understood backwards; but it must be lived forwards." Soren Kierkegaard
User
Posted 08 Jan 2017 at 11:49

Many thanks Marje... the weight of opinion does seem to be pro Enzo, but as you say the oncologist will doubtless give us some guidance. What's cheering is the fact that Enzo appears to give a health-boost; however long or short the duration it would be wonderful if my OH could feel better in himself and less battered by the PCA and the chemo and the various side effects. Sounds as if that might not be too much to hope for.


And yes the NHS is extraordinary. Hope it survives!


Eleanor


x

User
Posted 08 Jan 2017 at 11:51

Thanks Paul. Hope we have a similar positive experience - and that yours continues.


Cheers


Eleanor

User
Posted 10 Jan 2017 at 13:36

Hi Elanor


 


No problem with EITHER Enzo or Zoladex.....other than what it was expected that is....Hot flushes etc...


 


Regards

User
Posted 10 Jan 2017 at 13:45

Hi ColU_FC


The problem was not TAKING Prednisolone but Stopping it.


As you know you must stop Steroids like Prednisolone in stages over a certain number of days/months.


I just think my 20 Days Stopping time was not long enough.


It is hard to describe how I was feeling but here it is.....


Think about being in an Airplane that is going to crash....and while you are trying to make peace with God and death everyone around you is shouting, crying, screaming and so on.....now imagine this going on every waking hour of the day...and ANYTHING can trigger this Stress level...like for example a dog barking in the distance.


This went on for about two weeks.... until the SUICIDAL THOUGHTS started...IT WAS DARK...IF I did not have my pets to take care of I would surely have done myself in....IT WAS DARK!  This lasted another 10 days or so.


I have no doubt steroids can be life saving...but they can also be deadly.


Regards


 

Edited by member 10 Jan 2017 at 13:53  | Reason: Not specified

User
Posted 10 Jan 2017 at 15:41

Thanks Bill. Forewarned is forearmed.


I'm on daily Preds and will be for the full 30 weeks of Docetaxel chemo. Hence my interest in your experiences of coming off them.

User
Posted 08 Feb 2017 at 18:18

Do you have to have had chemo(docetaxel) before starting enzo.?
I don't feel the abbis and dexo are doing much good for my O/H, but the onco doesn't seem bothered even though his PSA has risen from late 50s to 98. My husband's PSA, that is, not the onco's!

User
Posted 08 Feb 2017 at 18:33

Originally Posted by: Online Community Member


Do you have to have had chemo(docetaxel) before starting enzo.?
I don't feel the abbis and dexo are doing much good for my O/H, but the onco doesn't seem bothered even though his PSA has risen from late 50s to 98. My husband's PSA, that is, not the onco's!



Jenny,


I'm sorry to tell you that if you have abbi you can't have enzo and vice versa. This is a NICE decision which they made since the cost of these drugs is very high and the fact that if one fails then it is very unlikely that the other will then work. My Onco told me that there was a 5% chance of abbi working after my enzo failed.


David

User
Posted 09 Feb 2017 at 09:03

Originally Posted by: Online Community Member


Do you have to have had chemo(docetaxel) before starting enzo.?
I don't feel the abbis and dexo are doing much good for my O/H, but the onco doesn't seem bothered even though his PSA has risen from late 50s to 98. My husband's PSA, that is, not the onco's!



 


Hi Jenny


I think docetaxel is in the bag of tricks IF other treatments don't work/stopped working/Mets are present.....


The only reason I was on abiraterone and Enzalutamide AT THE SAME TIME was because of a trial.....The "Regular" treatment is Zoladex 2-3 years + RT and/or RP....but then again I suppose it depends what your postcode is.


".....but the onco doesn't seem bothered even though his PSA has risen from late 50s to 98. My husband's PSA"


If that is true I think that he/she is in the wrong profession....since the PSA IS what they will use to judge how the treatment is going.


You didn't say much about the MRI/G.score etc...on your BIO! I assume the reason you OH is on docetaxel it is because of Mets?


 


Regards


 

 
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