Radium 223 Progress

Thanks for the update, Glen. We are still a bit behind you on this path, partly because another avenue is being explored (more about that in a week or two when we know more) but your OH's blood results sound like what might be expected - we were told that the Radium would have more effect on the ALPS than on the PSA. Have a lovely holiday, I know how precious these things are at this stage. And keep in touch.

Update following treatment 4 on 11 May.

For some reason PSA not measured by phlebotomy so guessing it's risen! Bone Markers slightly up at 128 but still within tolerance. Hb down at 9.6 - not the lowest it's been but they will keep an eye on this and maybe a transfusion on the cards.

Hubby is very tired, gets breathless easily and still has quite a bit of pain, however, he is taking no pain killers!

Had discussions what happens after the 6 treatments. Talked about a new trial which uses immunotherapy. Has to have had chemo (he has)and will need to send biopsies from original samples to see if the treatment has a chance of working for him. Will set the wheels in motion in 4 weeks time at treatment 5. Other than that it may be Cabazitaxel.

He gets very low with the treatment especially as he just cannot do the fell walking he used to do. I am in training for Wharfedale 3 Peaks, 22 miles over Birks Fell, Buckden Pike and Great Whernside from Kettlewell on 22 July and will raise money for PCUK.

Hope this post is of interest.

Regards

Glen

Great to hear from you Glen and the progress under radium 223. It is great he is holding his own and that there may be more plans further down the road. You are a trailblazer for this drug and I always watch with interest as may get there at some point. Hope it can begin to feel better in himself as time goes on! Thinking of you both.

Of course it is for at least two reasons:

1. Lots of us are headed in the direction of Radium 223.

2. Far more importantly we care about how you and Phil are getting on.

Fingers and toes remain permanently crossed for you.

Has your Onco ruled out giving Stilboestrol a try? How about asking about Hsp90 inhibitors?

http://community.prostatecanceruk.org/posts/t11706-New-drugs-for-aggressive-prostate-cancer--promising#post145585

It's got to be worth trying to get the pain under control isn't it? Everything I've read about PCa pain indicates it's easier to sort it the sooner you jump on it.

So sorry to hear that. I know exactly how you feel as my husband is at a similar stage to yours. Just come off enzalutamide as it had stopped working and now metastasised to chest lymphs. Had extensive skeletal mets on diagnosis in Dec 2012. He is due to start maintenance of weekly low dose docetaxel for five weeks with a view to going onto Cabazitaxel when it is available to us in August. He has previously had 10 cycles of docetaxel prior to the enzo. Not suitable for radium 223 due to chest lymph and stillboestrol ruled out by onco. It feels like a real roller coaster ride and far too real. Best wishes to your and your husband.